Possibility of Selenium Nanoparticles Manufactured by Glycyrrhiza glabra Extract and γ- irradiation to Suppress the Growth of Murine Tumor

  • Neamat Hanafi Ahmed National Center for Radiation research and Technology
  • Ahmed I. El-Batal
  • Lamiaa Ali Barakat Port Said University
  • Salma M. Khirallah Port Said University
Keywords: Glycyrrhiza glabra, selenium nanoparticles, Ehrlich carcinoma

Abstract

Glycyrrhiza glabra (Gg) is used in traditional medicine. The present study examine the possibility of Gg root extract and selenium nanoparticles (SeNPs) fabricate by Gg extract and γ- irradiation to suppress the growth of murine tumors. Ehrlich ascite carcinoma cells and 4 groups of Swiss albino mice were used. Solid Ehrlich carcinoma (EC) was induced by intramuscular injection of 2.5x106 cells. Mice were gavages by Gg extract or SeNPs. Tumor size, serum TNF-α, IFN-γ, Granzyme-B and Caspase-3 were evaluated. Cat, GSH, MDA, histopathological, apoptotic and necrotic examinations were studied in tumor tissues. Either Gg extract or SeNPs significantly inhibit tumor size, TNF-α, IFN-γ and MDA. On the other hand, elevation in Caspase-3 activity and Granzyme-B were predicted. Meanwhile, the histopathological, apoptotic and necrotic examinations were context with the previous results. From previous we conclude that Gg extract or SeNPs have the possibility to suppress the growth of Ehrlich carcinoma.

Author Biographies

Neamat Hanafi Ahmed, National Center for Radiation research and Technology

Radiation biology Department, National Canter for Radiation, Research and Technology,
Egyptian Atomic Energy Authority, Cairo, Egypt .

Ahmed I. El-Batal

Drug Radiation Research Department, National Canter for Radiation, Research and
Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.

Lamiaa Ali Barakat, Port Said University

Biochemistry Department, Faculty of Science, Port Said University, Port Said, Egypt.

Salma M. Khirallah, Port Said University

Biochemistry Department, Faculty of Science, Port Said University, Port Said, Egypt.

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Published
2019-03-02
How to Cite
Hanafi Ahmed, N., El-Batal, A. I., Barakat, L. A., & Khirallah, S. M. (2019). Possibility of Selenium Nanoparticles Manufactured by Glycyrrhiza glabra Extract and γ- irradiation to Suppress the Growth of Murine Tumor. Journal of Advance Research in Pharmacy & Biological Science (ISSN: 2208-2360), 5(2), 01-23. Retrieved from https://jiaats.com/ojs31/index.php/pbs/article/view/970

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