Possibility of Selenium Nanoparticles Manufactured by Glycyrrhiza glabra Extract and γ- irradiation to Suppress the Growth of Murine Tumor
Glycyrrhiza glabra (Gg) is used in traditional medicine. The present study examine the possibility of Gg root extract and selenium nanoparticles (SeNPs) fabricate by Gg extract and γ- irradiation to suppress the growth of murine tumors. Ehrlich ascite carcinoma cells and 4 groups of Swiss albino mice were used. Solid Ehrlich carcinoma (EC) was induced by intramuscular injection of 2.5x106 cells. Mice were gavages by Gg extract or SeNPs. Tumor size, serum TNF-α, IFN-γ, Granzyme-B and Caspase-3 were evaluated. Cat, GSH, MDA, histopathological, apoptotic and necrotic examinations were studied in tumor tissues. Either Gg extract or SeNPs significantly inhibit tumor size, TNF-α, IFN-γ and MDA. On the other hand, elevation in Caspase-3 activity and Granzyme-B were predicted. Meanwhile, the histopathological, apoptotic and necrotic examinations were context with the previous results. From previous we conclude that Gg extract or SeNPs have the possibility to suppress the growth of Ehrlich carcinoma.
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