Preparation and diagnosis of new Azo - barbiturate dyes

  • Ali Ghazi Kazim AL-Qadisiyah University - Education College – Chemistry Dep.
  • Abdullah Jawad Kadhim AL-Qadisiyah University - Education College – Chemistry Dep.
Keywords: Barbituric acid, thymol, quinol, phenlenediamine

Abstract

The research includes the preparation of new azo-barbiturate dyes derived from shiff bases prepared by reaction Barbituric acid & phenlenediamine and repellency bases by means of double-reaction of repellant bases with different phenolic compounds. These compounds were diagnosed using infrared techniques, ultraviolet-visible radiation, NMR proton and thin layer chromatography. All barbiturate dyes had absorption between (273 – 310) nm and showed hypsochromic shift from the corresponding azo dyes. The crystal structures of barbiturate dyes indicated that barbiturate ring is sterically hindered by phenol rings .

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References

1. B. Dickey & A. R. Gray. "Barbituric acid". Org. Synth.,(1943), Coll.
Vol., 2, p. 60 .
2. .Kauffman, George B. "Adolf von Baeyer and the naming of barbituric
acid," Journal of Chemical Education, (1980), 57 : 222–223.
3. Boyd E M, Pearl M. "Can nalorphine hydrochloride prevent respiratory
depression and death from overdose of barbiturates" , Canadian Medical
Association Journal, (1955), 73(1):35-8.
4. Koppanyi T, Fazekas J F. "Acute Barbiturate Poisoning Analysis and
Evaluation of Current Therapy[J]. American Journal of the Medical
Sciences", (1950), 220(5):559-576
5. Shulman A, Shaw F H, Cass N M, et al. "A New Treatment of Barbiturate
Intoxication"J. British Medical Journal, (1955), 1(4924):1238-44.
6. Bateman C H. "BARBITURATE POISONING" J. Lancet, (1963),
282(7303):357.
7. A khadim ," synthesis of new azo dyes via suzuki coupling ", (2014)
.college of science 12 (20), 66-72
8. "Barbiturates". Archived from the original on 7 November 2007.
Retrieved 2007-10-31, "Dorlands Medical Dictionary:hypnotic"
. Mercksource.com. Archived from the originalon ,(2008),12-11.
9. Brunton, Laurence L.; Lazo, John S.; Lazo Parker, Keith L.. "17: Hypnotics
and Sedatives". Goodman & Gilman's The Pharmacological Basis of
Therapeutics", (2006) , (11th ed.).
10. Mendels, J. "Criteria for selection of appropriate benzodiazepine hypnotic
therapy". (September 1991). J Clin Psychiatry. 52. Suppl: 42–6
11. Glass, J.; Lanctôt, K. L.; Herrmann, N.; Sproule, B. A.; Busto, U. E.
"Sedative hypnotics in older people with insomnia: meta-analysis of risks
and benefits".(November 2005). BMJ. 331 (7526).
12. Arulmurugan S, Kavitha PH, Venkatraman RP ." Biological activities of
Schiff base and its complexes: a review ". Rasayan J Chem . ,(2010) ,
3(3):385–410.
13. Przybylski P, Huczyński A, Pyta K, Brzezinski B, Bartl F." Biological
properties of Schiff bases and azo derivatives of phenols". Curr Org Chem
2009, 13: 124–148 .
14. Xu,H. and Zeng,X. "Synthesis of diaryl-azo derivatives as potential
antifungal agents ".Bio org.Med.Chem.Lett. ,(2010) ,20, 4193-4195 .
15. Hatice K."Synthesis & spectral characteerisation of novel azo-azomethine
dyes ", Turk.J.Chem. , (1999) , 23,67-71 .
16. Janeczek H, Sek D, Ostrowski S. " Similarities and differences between
azomethines and ketimines ", Spectrochim Acta A Mol Biomol Spectrosc,
(2007) , 66,1030-41.
17. Meghasham N. N. "Synthesis, Characterization & Antimicrobial
Activities of Substituted 2, 5-Disubstituted Phenyl-6-Substituted Phenyl
Sulfonamide / Azomethine / Azo. ", IJARCS ,( 2014) , 1, 70-86 .
18. S. Patai, Ed., "The Chemistry of the Carbon-Nitrogen Double Bond", J.
Wiley & Sons, (1970), London .
19. Muhammad A. A., Karamat M., "Synthesis, Characterization and Biological
Activity of Schiff Bases" , IPCBEE ,(2011) , 10 , 1-7 .
20. C. J. Patil et al. , " Synthesis & characterization of ketimines from 1-
acetyl naphthalene with derivatives of aniline ", Der Pharma Chemica,
(2016) , 8 (1) , 99-103 .
21. C. J. Patil and C. A. Nehete , " Synthesis & characterization of ketimines
from 5-Chloro-4-methyl-2-hydroxy-acetophenone with disubstituted
anilines " , Der Pharma Chemica, (2015) , 6(10) , 1-6 .
22. A. Saxena , "Synthesis and characterization of schiff base salicylaldehyde
and thiohydrazones and its metal complexes " , Pelagia Research Library,
(2013) , 4(4):152-154 .
23. Prakash, C.R., Raja, S., "Synthesis and Antimicrobial Activities of Some
Novel Schiff Bases of 5-Substituted Isatin Derivatives ", Rasayan Journal
of Chemistry, (2009) , 2, 960- 968.
24. SANDRA S. & DOO Aura. ," SYNTHESIS AND STRUCTURE OF
VANILLIN AZOMETHINES" , CI&CEQ ,(2009) , 15 (4) 279−281 .
25. R.K. Agarwal, S. Prasad, Bioinorg , "Synthesis, Characterization &
Antimicrobial Activities of azo methines of 3-methoxy-4-butoxy
benzaldehyde ", Chem. Appl. , (2005), 3, 271-288 .
26. Furniss.S.Brian , Vogels textbook of practical organic chemistry " , 5th
edition , John Wiley & Sons. Inc. , NY ,(1989 ).
27. Abdullah J.Kadim and Ali G.Kadhim" Synthesis & characterization some
of α, β – unsaturated aliphatic ketones derivatives " , AL-Qadisiyah
Journal for science, (2010) , 15 ,2, 45-62 .
28. Basser,M.A. & V.D.Phule , "Synthesis & antimicrobial activity of some
new Schiff bases " , Orient.J.CHem. , (2000) , 16 , 553 .
29. R.M.Silverstein , " Spectrometric identification of organic compounds" ,
5th edition ,Wiley , NY ,(1991).
30. Schraml, Jan; Bellama, Jon M. ," Two-Dimensional NMR Spectrocopy"
New York: Wiley. , (1988) , pp. 28–33, 49–50
31. Wadher.S.J. , Puranik M.P. &Karande N.A. ,"Synthesis & Biological
evalution sciff base of dapsone &their derivative as antimicrobial agents",
Inter.J.Pharm.Tech.Res. , (2009) , 1 , 22-33 .
32. Jufe, G. S. "New hypnotics: perspectives from sleep physiology". Vertex
(July–August 2007). 18 (74): 294–9 .
33. Löscher, W.; Rogawski, M. A. "How theories evolved concerning the
mechanism of action of barbiturates".(2012). Epilepsia. 53: 12–25.
34. Huedo-Medina, T. B.; Kirsch, I.; Middlemass, J.; Klonizakis, M.; Siriwardena,
A. N. "Effectiveness of non-benzodiazepine hypnotics in treatment of adult
insomnia: meta-analysis of data submitted to the Food and Drug
Administration"(17 December 2012) , BMJ. 345: e8343.
Published
2018-12-29
How to Cite
Kazim, A. G., & Kadhim, A. J. (2018). Preparation and diagnosis of new Azo - barbiturate dyes. Journal of Advance Research in Applied Science (ISSN: 2208-2352), 5(12), 01-10. Retrieved from https://jiaats.com/ojs31/index.php/as/article/view/936